Ultrastructural changes and inflammatory processes of day-dependent cisplatin administration on rat cardiac tissue

Aim: Cisplatin (CP) is used to treat a variety of cancers as chemotherapeutic agent. This drug has also severe side effects and its use exhibits serious toxicity in number organs, including kidney heart. The aim the present study was evaluate ultrastructural inflammatory changes induced by CP treatment rat cardiac tissue time-dependent manner.
 Material Methods: Rats were randomly divided into three experimental groups; control (only saline), D2 (treated with 2.5 mg/kg/day for 2 days), D7 7 days). Cardiac tissues examined under an electron microscope. Inflammation markers tumor necrosis factor-α (TNF-α) interleukin 1β (IL-1β) analyzed immunohistochemistry. In addition, electrocardiography performed measure electrical activity.
 Results: analysis group revealed that myofibrils disrupted disorganized, mitochondria degenerated, interstitial edema developed. When compared groups, there noticeable increase level TNF-α IL-1β expression according immunohistochemistry results. Electrocardiography showed RR interval longer than groups.
 Conclusion: days damaged morphology tissue. Therefore, these findings suggest potential therapeutic approaches reduce mitochondrial damage inflammation against caused may provide clinically significant prevention when using extended period time.